Prevention

Preventing Type 1 Diabetes: Advancements in Prevention

Understanding Type 1 Diabetes

Type 1 diabetes (T1D) is a chronic disease where the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. This results in a lifelong dependence on insulin therapy to regulate blood sugar levels. Unlike type 2 diabetes, which is often associated with lifestyle and genetic factors, T1D can develop in people of any age without clear preventable causes.

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Preventing T1D has been a significant challenge due to its autoimmune nature and the complex interplay of genetic and environmental factors. While we do not yet have a guaranteed method to prevent T1D, significant progress has been made in research and treatment options.

Getting screened for type 1 diabetes is crucial because if you test positive for antibodies, you can qualify for the administration of Tzield—a drug used to delay the onset of T1D. Learn more about the screening process here. 

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One of the most promising advancements in T1D prevention is Tzield (teplizumab-mzwv). Tzield is a groundbreaking treatment developed to delay the onset of type 1 diabetes in individuals at high risk. Tzield is approved for individuals who are at risk ages 8 and older.

 

Here’s how Tzield is making a difference:

  • What is Tzield?

    Tzield is a man-made protein that mimics the function of human antibodies, designed to target and modify the immune system's activity. It specifically targets immune cells that attack the insulin-producing beta cells in the pancreas. By addressing the underlying autoimmune response, Tzield aims to preserve beta cell function and delay the progression of T1D in at-risk individuals. 

  • How Does Tzield Work?
    1. Immune System Modulation: Tzield works by modifying the immune system’s response. It targets certain immune cells that are involved in the destruction of beta cells, reducing their activity and potentially preserving the body's ability to produce insulin.
    2. Delay of Onset: Clinical studies have shown that Tzield can delay the onset of type 1 diabetes in individuals who have already shown early signs of the disease. This delay can provide individuals and families more time to prepare and manage the condition proactively. Learn more on the Barbara Davis Center website.
    3. Personalized Approach: Tzield is typically used for individuals who are identified as being at high risk for developing T1D, often determined through autoantibody and glycemic testing and other biomarkers. This targeted approach helps in offering the treatment to those who are most likely to benefit from it.
  • What are the benefits of Tzield?
    • Early Intervention: By intervening before full-blown diabetes develops, Tzield offers the potential to significantly improve quality of life and reduce the burden of managing diabetes from a young age.
    • Preservation of Beta Cell Function: Preserving beta cell function means maintaining the body’s ability to produce insulin, which is crucial for managing blood sugar levels and preventing complications associated with T1D.
    • Innovative Treatment: As one of the first treatments approved for delaying T1D, Tzield represents a major advancement in diabetes care and prevention.

  • What's next?

    The introduction of Tzield marks an exciting development in the fight against type 1 diabetes. Ongoing research and clinical trials continue to explore how we can better use Tzield and other potential therapies to prevent or delay T1D more effectively.

  • What Can You Do?
    • Stay Informed: Keep up with the latest research and advancements in T1D prevention and treatment.
    • Consult Healthcare Providers: If you or a family member is at high risk for T1D, discuss the potential benefits of Tzield with a healthcare provider.
    • Support Research: Contributing to diabetes research organizations can help fund innovative treatments and advancements in T1D prevention.

While type 1 diabetes remains a complex and challenging condition, advancements like Tzield bring hope and promise. By addressing the autoimmune component of T1D and delaying its onset, we are taking significant steps toward better management and potential prevention of this lifelong disease.

 

For more information about Tzield and its availability, consult with your healthcare provider or visit our research and treatment updates page.

Disclaimer: Tzield is a prescription medication with specific indications and potential side effects. Consult your healthcare provider for more information about its suitability for you or your loved ones.