Researchers at the Barbara Davis Center work on everything from basic laboratory-centered research to international clinical trials and studies. Some of these projects include:
CACTI: In 2000, a prospective cohort study was initiated to examine early detection of heart disease in 1,400 adult patients with type 1 diabetes and controls to better define the causes of premature heart disease and other long-term complications in patients with type 1 diabetes. This Coronary Artery Calcification in Type 1 (CACTI) Study has used electron beam computed tomography to detect and monitor progression of calcification of the coronary arteries over three visits so far, and will be conducting a 12-year examination starting in the fall of 2013. This study has discovered a number of novel genetic, metabolic and inflammatory factors of potential importance to prevention of diabetic complications.
CEDAR/ROSE Study: (Research on gluten Sensitive Entropathy, Growth and bone density in Celiac Disease), is assessing whether having a celiac disease marker is associated with alterations in growth, and bone strength in patients with type 1 diabetes and in non-diabetic subjects that have tested positive for the celiac autoantibody (tTG). In addition, the study will assess whether these alterations improve with treatment with a gluten-free diet. There are currently 353 subjects enrolled (127 non-diabetic subjects from the DAISY study and 226 type1 diabetic subjects), these subjects will be followed over the next three years to define predictors of clinically relevant outcomes: growth, micronutrient efficiencies, bone mineralization and quality of life.
DAISY: The Diabetes Autoimmunity Study in the Young (DAISY) has screened for diabetes genes in over 31,000 newborns from families where nobody has diabetes as well as over 1,800 young relatives of people with the disease. Over 2,500 high-risk infants have been followed for up to 17 years to learn how genes and the environment interact to trigger the onset of type 1 diabetes. In DAISY participants, certain genetic backgrounds, early dietary exposures and infections have been found to be associated with diabetes
TEDDY – The Environmental Determinants of Diabetes in the Young study seeks to determine the cause of type 1 diabetes by looking at genetic and environmental factors including childhood illness, diet, medications, vitamins, allergies, vaccinations, and sociological and psychological issues.
TYPE 1 DIABETES TRIALNET – TRIALNET is an international network of researchers who are exploring ways to prevent, delay, and reverse the progression of type 1 diabetes by identifying risk factors and developing experimental treatments to preserve insulin production.
T1DGC – The Type 1 Diabetes Genetic Consortium works with researchers and data from around the globe to learn what role genetics might play in the incidence of type 1 diabetes.
ITN – The Immune Tolerance Network is a consortium of researchers who investigate autoimmune diseases and focus on treatments that help the body recognize the difference between helpful and harmful particles so that the immune system can function properly.
Twin Study – This study looks at twins to help determine how genes affect the development, treatment, and prevention of type 1 diabetes.
Metabolic Control Study – This study works exclusively with newly diagnosed patients to learn if tight blood sugar control at the onset of diabetes can help the body continue to produce its own insulin.
Artificial Pancreas Studies – Research is underway to “close the loop” so that continuous glucose monitors can work with pumps to stop insulin delivery and reverse nocturnal hypoglycemia.